NSC 109555 ditosylate

Name: NSC 109555 ditosylate
Brand: Tocris Bioscience
SKU: 3034

Tocris Bioscience, part of Bio-Techne | Catalog # 3034

Citations (2)

COA / SDS

Selective Chk2 inhibitor

Key Product Details

Chemical Name:	2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)
Purity:	≥98%
Molecular Weight:	752.86 kDa

View Full Technical Details for NSC 109555 ditosylate

Technical Data
Citations

Biological Activity for NSC 109555 ditosylate

NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor (IC₅₀ = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC₅₀ > 10 μM). Inhibits histone H1 phosphorylation (IC₅₀ = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Technical Data for NSC 109555 ditosylate

M. Wt	752.86 kDa
Formula	C₁₉H₂₄N₁₀O.2C₇H₈O₃S
Storage	Store at -20°C
Purity	≥98%
CAS Number	66748-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 109555 ditosylate

Solubility

Soluble Soluble to 10 mM in DMSO

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References for NSC 109555 ditosylate

References are publications that support the biological activity of the product.

Byczkowski et al. Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol., 1981;30:2851 PMID: 6895596
Byczkowski et al. Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res., 1982;42:3592 PMID: 6896674
Jobson et al. Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol., 2007;72:876 PMID: 17616632