NSC 109555 ditosylate

Name: NSC 109555 ditosylate
Brand: Tocris Bioscience
SKU: 3034

Tocris Bioscience, part of Bio-Techne | Catalog # 3034

Citations (2)

COA / SDS

Selective Chk2 inhibitor

Key Product Details

Description:	Selective Chk2 inhibitor
Alternative Names:	DDUG
Chemical Name:	2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)
Purity:	≥98% (HPLC)
Molecular Weight:	752.86

View Full Technical Details for NSC 109555 ditosylate

Technical Data
Citations

Biological Activity for NSC 109555 ditosylate

NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor (IC₅₀ = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC₅₀ > 10 μM). Inhibits histone H1 phosphorylation (IC₅₀ = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Technical Data for NSC 109555 ditosylate

M. Wt	752.86
Formula	C₁₉H₂₄N₁₀O.2C₇H₈O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	66748-43-4
PubChem ID	12449850
InChi Key	DIQGNVANOSOABS-XMDRLFCYSA-N
Smiles	O=C(NC2=CC=C(/C(C)=N/NC(N)=N)C=C2)NC1=CC=C(/C(C)=N/NC(N)=N)C=C1.CC3=CC=C(S(=O)(O)=O)C=C3.CC4=CC=C(S(=O)(O)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 109555 ditosylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.53	10

Preparing Stock Solutions for NSC 109555 ditosylate

The following data is based on the product molecular weight 752.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.28 mL	66.41 mL	132.83 mL
0.5 mM	2.66 mL	13.28 mL	26.57 mL
1 mM	1.33 mL	6.64 mL	13.28 mL
5 mM	0.27 mL	1.33 mL	2.66 mL

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References for NSC 109555 ditosylate

References are publications that support the biological activity of the product.

Byczkowski Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 1982 PMID: 6896674
Jobson Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 2007 PMID: 17616632
Byczkowski Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 1981 PMID: 6895596