NSC 23766

Name: NSC 23766
Brand: Tocris Bioscience
SKU: 2161
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2161

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Citations (298)

COA / SDS

Selective inhibitor of Rac1-GEF interaction; antioncogenic

Key Product Details

Description:	Selective inhibitor of Rac1-GEF interaction; antioncogenic
Chemical Name:	N⁶-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	530.97

View Full Technical Details for NSC 23766

Technical Data
Citations / Reviews (1)

Biological Activity for NSC 23766

NSC 23766 is a selective inhibitor of Rac1-GEF interaction. NSC 23766 prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC₅₀ ~ 50 μM) without affecting Cdc42 or RhoA activation. The compound inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotypes in prostate cancer cells. NSC 23766 also inhibits mammary carcinoma cell invasion in vitro and inhibits mammary tumor progression and metastasis in a mouse model.

Compound Libraries for NSC 23766

NSC 23766 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NSC 23766

M. Wt	530.97
Formula	C₂₄H₃₅N₇.3HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1177865-17-6
PubChem ID	16759159
InChi Key	CPUHORIUXPQCHW-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(C)=CC(NC2=CC=C3N=C(C)C=C(N)C3=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 23766

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	53.1	100
	DMSO	53.1	100

Preparing Stock Solutions for NSC 23766

The following data is based on the product molecular weight 530.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.42 mL	18.83 mL
5 mM	0.38 mL	1.88 mL	3.77 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for NSC 23766

References are publications that support the biological activity of the product.

Floerchinger Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging. Cell Rep. 2021 PMID: 34525350
Gao Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc.Natl.Acad.Sci.USA 2004 PMID: 15128949