NSC 636819

Name: NSC 636819
Brand: Tocris Bioscience
SKU: 5287
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5287

Citations (4)

COA / SDS

KDM4A/KDM4B inhibitor

Key Product Details

Description:	KDM4A/KDM4B inhibitor
Chemical Name:	1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Purity:	≥98% (HPLC)
Molecular Weight:	510.15

View Full Technical Details for NSC 636819

Technical Data
Citations

Biological Activity for NSC 636819

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Technical Data for NSC 636819

M. Wt	510.15
Formula	C₂₂H₁₂Cl₄N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1618672-71-1
PubChem ID	6288112
InChi Key	YYZPXBXVBQSBDG-IJIVKGSJSA-N
Smiles	ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 636819

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.1	10

Preparing Stock Solutions for NSC 636819

The following data is based on the product molecular weight 510.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.60 mL	98.01 mL	196.02 mL
0.5 mM	3.92 mL	19.60 mL	39.20 mL
1 mM	1.96 mL	9.80 mL	19.60 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

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References for NSC 636819

References are publications that support the biological activity of the product.

Chu KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 2014 PMID: 24971742