NSC 87877

Name: NSC 87877
Brand: Tocris Bioscience
SKU: 2613

Tocris Bioscience, part of Bio-Techne | Catalog # 2613

Citations (39)

COA / SDS

Potent inhibitor of shp2 and shp1 PTP

Discontinued Product

2613 has been discontinued. View all Protein Tyrosine Phosphatase Inhibitors products.

Key Product Details

Description:	Potent inhibitor of shp2 and shp1 PTP
Chemical Name:	8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	459.45

View Full Technical Details for NSC 87877

Technical Data
Citations

Biological Activity for NSC 87877

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC₅₀ values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data for NSC 87877

M. Wt	459.45
Formula	C₁₉H₁₃N₃O₇S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	56990-57-9
PubChem ID	5459322
InChi Key	BIQBDHSYQMHHPU-CJLVFECKSA-N
Smiles	OC2=C(/N=N/C3=CC=C(C=C(S(=O)(O)=O)C=C4)C4=C3)C=C(S(=O)(O)=O)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NSC 87877

References are publications that support the biological activity of the product.

Zhao Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 2007 PMID: 17659592
Redonde hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 2007 PMID: 17892531
Chen Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 2006 PMID: 16717135

NSC 87877

Tocris Bioscience, part of Bio-Techne | Catalog # 2613

Key Product Details

Biological Activity for NSC 87877

Technical Data for NSC 87877

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NSC 87877

Product Documents for NSC 87877

COA

Certificate of Analysis

SDS

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