NX 5948

Name: NX 5948
Brand: Tocris Bioscience
SKU: 8856

Tocris Bioscience, part of Bio-Techne | Catalog # 8856

COA / SDS

Potent and selective BTK Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective BTK Degrader (PROTAC^®)
Chemical Name:	3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	806.97

View Full Technical Details for NX 5948

Technical Data
Citations

Biological Activity for NX 5948

NX 5948 is a potent and selective Bruton's tyrosine kinase (BTK) Degrader (PROTAC^®) (DC₅₀ = <1 nM; D_max = 98%). Comprises a BTK binding moiety joined by a linker to cereblon (CRBN) ligand. In vitro, NX-5948 very potently, rapidly and completely degrades BTK in primary human B cells (DC₅₀ = 0.034 nM). NX 5948 degrades BTK, inhibits tumor growth and increases survival in TMD8 xenograft mouse models of brain maligancy. Reduces inflammation and symptom severity in a mouse model of collagen-induced arthritis. NX 5948 is orally bioavailable and blood brain barrier penetrant.

Licensing Information

Sold under license from Nurix Therapeutics

Technical Data for NX 5948

M. Wt	806.97
Formula	C₄₂H₅₄N₁₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2649400-34-8
PubChem ID	156464216
InChi Key	HPTPDBYCFHFWJG-CWTKIQHKSA-N
Smiles	NC(C1=C(N=C(N2C[C@H](N3C(N(CC3)C)=O)CCC2)C=N1)NC4=CC=C(C5CCN(CC5)CC6CCN(C7=CN=C(C(N[C@@H]8C(NC(CC8)=O)=O)=O)C=C7)CC6)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NX 5948

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.35	50

Preparing Stock Solutions for NX 5948

The following data is based on the product molecular weight 806.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.48 mL	12.39 mL	24.78 mL
2.5 mM	0.50 mL	2.48 mL	4.96 mL
5 mM	0.25 mL	1.24 mL	2.48 mL
25 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Product Documents for NX 5948

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.