OB-1

Name: OB-1
Brand: Tocris Bioscience
SKU: 6545

Tocris Bioscience, part of Bio-Techne | Catalog # 6545

Citations (2)

COA / SDS

Stomatin-like protein-3 (STOML3) oligomerization inhibitor

Key Product Details

Description:	Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Chemical Name:	Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	407.38

View Full Technical Details for OB-1

Technical Data
Citations

Biological Activity for OB-1

OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.

Compound Libraries for OB-1

OB-1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OB-1

M. Wt	407.38
Formula	C₂₁H₁₇N₃O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	300803-69-4
PubChem ID	1113704
InChi Key	UJHGRDVYTTVJFD-UHFFFAOYSA-N
Smiles	CCOC(C1=C(C2=CC=CC=C2)OC3=CC=C(C=C13)OC4=C([N+]([O-])=O)N=CN4C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OB-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.37	50

Preparing Stock Solutions for OB-1

The following data is based on the product molecular weight 407.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.91 mL	24.55 mL	49.09 mL
2.5 mM	0.98 mL	4.91 mL	9.82 mL
5 mM	0.49 mL	2.45 mL	4.91 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

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References for OB-1

References are publications that support the biological activity of the product.

Wetzel Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 2017 PMID: 27941788