Ogerin

Name: Ogerin
Brand: Tocris Bioscience
SKU: 5722

Tocris Bioscience, part of Bio-Techne | Catalog # 5722

Citations (4)

COA / SDS

Selective positive allosteric modulator at GPR68

Key Product Details

Description:	Selective positive allosteric modulator at GPR68
Chemical Name:	2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	307.35

View Full Technical Details for Ogerin

Technical Data
Citations

Biological Activity for Ogerin

Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC₅₀ = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.

Compound Libraries for Ogerin

Ogerin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.

Technical Data for Ogerin

M. Wt	307.35
Formula	C₁₇H₁₇N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1309198-71-7
PubChem ID	56707820
InChi Key	MDGIEDNDSFMSLP-UHFFFAOYSA-N
Smiles	NC1=NC(NCC2=CC=CC=C2)=NC(C3=CC=CC=C3CO)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ogerin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.73	100
	ethanol	6.15	20

Preparing Stock Solutions for Ogerin

The following data is based on the product molecular weight 307.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for Ogerin

References are publications that support the biological activity of the product.

Huang Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 2015 PMID: 26550826