OICR 9429

Name: OICR 9429
Brand: Tocris Bioscience
SKU: 5267

Tocris Bioscience, part of Bio-Techne | Catalog # 5267

Citations (4)

COA / SDS

High affinity and selective WDR5 antagonist

Key Product Details

Chemical Name:	N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for OICR 9429

OICR 9429 is a high affinity WDR5 antagonist (K_d = 93 nM; IC₅₀ = 64 nM); disrupts WDR5-MLL interaction. Exhibits selectivity for WDR5 over 22 methyltransferases and a panel of kinases, GPCRs, ion channels, and transporters. Reduces viability of acute myeloid leukemia cells in vitro. Also disrupts MLL1-RbBP5 interaction.

To request the negative control for OICR 9429, please fill out the OICR 0547 request form on the SGC website.

Technical Data for OICR 9429

Formula	C₂₉H₃₂F₃N₅O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1801787-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OICR 9429

Solubility

Soluble Soluble to 50 mM in DMSO

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References for OICR 9429

References are publications that support the biological activity of the product.

Getlik et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J.Med.Chem., 2016;59:2478 PMID: 26958703
Grebien et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat.Chem.Biol., 2015;11:571 PMID: 26167872

OICR 9429

Tocris Bioscience, part of Bio-Techne | Catalog # 5267

Key Product Details

Biological Activity for OICR 9429

Technical Data for OICR 9429

Solubility for OICR 9429

Dilution Calculator

Reconstitution Calculator

References for OICR 9429

Product Documents for OICR 9429

COA

Certificate of Analysis

SDS

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