Olopatadine hydrochloride

Name: Olopatadine hydrochloride
Brand: Tocris Bioscience
SKU: 4241

Tocris Bioscience, part of Bio-Techne | Catalog # 4241

Citations (2)

COA / SDS

H1 antagonist; ocular antiallergic agent

Key Product Details

Chemical Name:	(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity:	≥99%
Molecular Weight:	373.87 kDa

View Full Technical Details for Olopatadine hydrochloride

Technical Data
Citations

Biological Activity for Olopatadine hydrochloride

Olopatadine hydrochloride is a histamine H₁ receptor antagonist (K_i = 31.6 nM). Inhibits the release of histamine, prostaglandin D₂ and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Technical Data for Olopatadine hydrochloride

M. Wt	373.87 kDa
Formula	C₂₁H₂₃NO₃.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	140462-76-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Olopatadine hydrochloride

Solubility

Soluble Soluble to 75 mM in water and to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Olopatadine hydrochloride

References are publications that support the biological activity of the product.

Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K, Nunomura S, Hayama K, Terui T, Ra C, Okayama Y Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol, 2014;134(3):622-633.e9. 2014 PMID: 24954276
Tamura et al. Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology, 2007;81:118 PMID: 17962722