ONO 2506

Name: ONO 2506
Brand: Tocris Bioscience
SKU: 4530

Tocris Bioscience, part of Bio-Techne | Catalog # 4530

Citations (4)

COA / SDS

Inhibits S-100β synthesis; neuroprotective

Key Product Details

Description:	Inhibits S-100β synthesis; neuroprotective
Alternative Names:	Arundic acid
Chemical Name:	(2R)-2-Propyloctanoic acid
Molecular Weight:	186.29

View Full Technical Details for ONO 2506

Technical Data
Citations

Biological Activity for ONO 2506

ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

Technical Data for ONO 2506

M. Wt	186.29
Formula	C₁₁H₂₂O₂
Storage	Store at +4°C
CAS Number	185517-21-9
PubChem ID	208925
InChi Key	YCYMCMYLORLIJX-SNVBAGLBSA-N
Smiles	CCC[C@H](CCCCCC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ONO 2506

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.63	100
	ethanol	18.63	100

Preparing Stock Solutions for ONO 2506

The following data is based on the product molecular weight 186.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.37 mL	26.84 mL	53.68 mL
5 mM	1.07 mL	5.37 mL	10.74 mL
10 mM	0.54 mL	2.68 mL	5.37 mL
50 mM	0.11 mL	0.54 mL	1.07 mL

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References for ONO 2506

References are publications that support the biological activity of the product.

Tateishi Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 2002 PMID: 12045671
Mori Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16709678
Kato Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 2004 PMID: 15567338