ONO 6818

Name: ONO 6818
Brand: Tocris Bioscience
SKU: 5651

Tocris Bioscience, part of Bio-Techne | Catalog # 5651

Citations (2)

COA / SDS

High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active

Key Product Details

Description:	High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
Chemical Name:	5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	452.51

View Full Technical Details for ONO 6818

Technical Data
Citations

Biological Activity for ONO 6818

ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (K_i = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Compound Libraries for ONO 6818

ONO 6818 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ONO 6818

M. Wt	452.51
Formula	C₂₃H₂₈N₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	208848-19-5
PubChem ID	216294
InChi Key	YSIHYROEMJSOAS-UHFFFAOYSA-N
Smiles	O=C(NC(C(C)C)C(C1=NN=C(C(C)(C)C)O1)=O)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ONO 6818

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.25	100

Preparing Stock Solutions for ONO 6818

The following data is based on the product molecular weight 452.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for ONO 6818

References are publications that support the biological activity of the product.

Aoshiba Serine proteases increase oxidative stress in lung cells. Am.J.Physiol.Lung Cell Mol.Physiol. 2001 PMID: 11504681
Stevens AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J.Pharmacol.Exp.Ther. 2011 PMID: 21791628
Hirota Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J.Vet.Med.Sci. 2004 PMID: 15528853