Orexin A (human, rat, mouse)

Name: Orexin A (human, rat, mouse)
Brand: Tocris Bioscience
SKU: 1455
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1455

(1)

Citations (14)

COA / SDS

Endogenous agonist at OX1 and OX2

Key Product Details

Description:	Endogenous agonist at OX₁ and OX₂
Purity:	≥95% (HPLC)
Molecular Weight:	3561.12

View Full Technical Details for Orexin A (human, rat, mouse)

Technical Data
Citations / Reviews (1)

Biological Activity for Orexin A (human, rat, mouse)

Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (K_i values are 20 and 38 nM for OX₁ and OX₂ receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.

Technical Data for Orexin A (human, rat, mouse)

M. Wt	3561.12
Formula	C₁₅₂H₂₄₃N₄₇O₄₄S₄
Single Letter Sequence	XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (Modifications: X = Glp, Disulfide bridges: 6-12, 7-14, Leu-33 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	205640-90-0
PubChem ID	90470982
InChi Key	IXODJSWYPSZUCI-IIIOAANCSA-N
Smiles	[H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Orexin A (human, rat, mouse)

Solubility

Soluble to 1mg/ml in water

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References for Orexin A (human, rat, mouse)

References are publications that support the biological activity of the product.

Kaczmarek Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions. J.Physiol.Pharmacol. 2017 PMID: 29375041
Forte Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat.Commun. 2021 PMID: 34675233
Sakurai Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 1998 PMID: 9491897
Smart Orexins: a new family of neuropeptides. Br.J.Anaesth. 1999 PMID: 10690128
Kilduff and Peyron The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 2000 PMID: 10906799