Oseltamivir phosphate

Name: Oseltamivir phosphate
Brand: Tocris Bioscience
SKU: 7224

Tocris Bioscience, part of Bio-Techne | Catalog # 7224

COA / SDS

Influenza virus neuraminidase inhibitor; antiviral prodrug

Key Product Details

Description:	Influenza virus neuraminidase inhibitor; antiviral prodrug
Alternative Names:	GS 4104
Chemical Name:	Ethyl (3R,4R,5S)-4-Acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	410.4

View Full Technical Details for Oseltamivir phosphate

Technical Data
Citations

Biological Activity for Oseltamivir phosphate

Oseltamivir phosphate is a viral neuraminidase inhibitor prodrug; metabolized to GS 4071. Metabolite exhibits potent inhibition of neuraminidase from multiple influenza strains (IC₅₀ values range from 0.3 to 2 nM). Inhibits cellular effects of influenza infection in vitro (IC₅₀ values range from 0.6 to 150 nM). Displays highest potency against H1N1 and H3N2 influenza A strains. Inhibits H1N1 influenza infection in mice.

Compound Libraries for Oseltamivir phosphate

Oseltamivir phosphate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Oseltamivir phosphate

M. Wt	410.4
Formula	C₁₆H₂₈N₂O₄.H₃PO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	204255-11-8
PubChem ID	78000
InChi Key	PGZUMBJQJWIWGJ-ONAKXNSWSA-N
Smiles	O[P](O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oseltamivir phosphate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.04	100
	water	41.04	100

Preparing Stock Solutions for Oseltamivir phosphate

The following data is based on the product molecular weight 410.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Molarity Calculator

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Reconstitution Calculator

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References for Oseltamivir phosphate

References are publications that support the biological activity of the product.

Mendel Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob.Agents Chemother. 1998 PMID: 9517945
Kim Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J.Am.Chem.Soc. 1997 PMID: 16526129