OX 04528

Name: OX 04528
Brand: Tocris Bioscience
SKU: 8131

Tocris Bioscience, part of Bio-Techne | Catalog # 8131

COA / SDS

Highly potent and selective GPR84 agonist

Key Product Details

Description:	Highly potent and selective GPR84 agonist
Chemical Name:	3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine-1-oxide
Purity:	≥98% (HPLC)
Molecular Weight:	365.28

View Full Technical Details for OX 04528

Technical Data
Citations

Biological Activity for OX 04528

OX 04528 is a highly potent and selective GPR84 agonist. It inhibits cAMP production in CHO cells expressing human GPR84 (EC₅₀ = 6 pM) and shows no β-arrestin recruitment. Exhibits selectivity for GPR84 over FFA1, FFA4, and CB2 receptors. In vivo, OX 04528 shows a half-life of 58 minutes following oral dosing at 10 mg/kg in mouse pharmacokinetic studies. OX 04528 is orally bioavailable.

Technical Data for OX 04528

M. Wt	365.28
Formula	C₁₆H₁₃F₆NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3028055-45-7
PubChem ID	170453166
InChi Key	DPLHUGXFERHOJE-UHFFFAOYSA-N
Smiles	[O-][N+]1=CC(CCCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OX 04528

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.53	100
	ethanol	36.53	100

Preparing Stock Solutions for OX 04528

The following data is based on the product molecular weight 365.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.69 mL	27.38 mL
5 mM	0.55 mL	2.74 mL	5.48 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for OX 04528

References are publications that support the biological activity of the product.

Wang Development of highly potent, G-protein pathway biased, selective, and orally bioavailable GPR84 agonists. J.Med.Chem. 2024 PMID: 38146625