Ozanimod

Name: Ozanimod
Brand: Tocris Bioscience
SKU: 7663

Tocris Bioscience, part of Bio-Techne | Catalog # 7663

Citations (4)

COA / SDS

Potent and selective S1P1 and S1P5 agonist

Key Product Details

Description:	Potent and selective S1P₁ and S1P₅ agonist
Chemical Name:	5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	404.46

View Full Technical Details for Ozanimod

Technical Data
Citations

Biological Activity for Ozanimod

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P₁) and 5 (S1P₅) agonist (EC₅₀ values are 0.41 and 11 nM, respectively, in a [³⁵S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P₅, and >10,000-fold selectivity over S1P_2-4. In vitro, Ozanimod induces sustained S1P₁ receptor internalization and degradation in S1P₁ receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.

Compound Libraries for Ozanimod

Ozanimod is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ozanimod

M. Wt	404.46
Formula	C₂₃H₂₄N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1306760-87-1
PubChem ID	52938427
InChi Key	XRVDGNKRPOAQTN-FQEVSTJZSA-N
Smiles	N(CCO)[C@@H]1C=2C(=C(C=CC2)C=3N=C(ON3)C4=CC(C#N)=C(OC(C)C)C=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ozanimod

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.45	100

Preparing Stock Solutions for Ozanimod

The following data is based on the product molecular weight 404.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.72 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for Ozanimod

References are publications that support the biological activity of the product.

Selkirk Deconstructing the pharmacological contribution of sphingosine-1 phosphate receptors to mouse models of multiple sclerosis using the species selectivity of ozanimod, a dual modulator of human sphingosine 1-phosphate receptor subtypes 1 and 5. J.Pharmacol.Exp.Ther. 2021 PMID: 34535564
R Taylor Meadows Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus. PLoS One 2018 PMID: 29608575
Scott Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune diseasemodifying activity. Br.J.Pharmacol. 2016 PMID: 26990079