P110

Name: P110
Brand: Tocris Bioscience
SKU: 6897

Tocris Bioscience, part of Bio-Techne | Catalog # 6897

Citations (6)

COA / SDS

Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable

Key Product Details

Description:	Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
Purity:	≥95% (HPLC)
Molecular Weight:	2411.8

View Full Technical Details for P110

Technical Data
Citations

Biological Activity for P110

P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.

Technical Data for P110

M. Wt	2411.8
Formula	C₁₀₀H₁₇₉N₄₅O₂₅
Single Letter Sequence	YGRKKRRQRRRGGDLLPRGS (Modification: Ser-20 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2770267-63-3
InChi Key	TYQHBBMTJWPEDH-VZOPDNRXSA-N
Smiles	[H]N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N)=O)CO)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC2=CC=C(C=C2)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for P110

Solubility

Soluble to 1mg/ml in water

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References for P110

References are publications that support the biological activity of the product.

Filichia Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 2016 PMID: 27619562
Qi A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 2013 PMID: 23239023