PA 8

Name: PA 8
Brand: Tocris Bioscience
SKU: 6657

Tocris Bioscience, part of Bio-Techne | Catalog # 6657

Citations (1)

COA / SDS

PAC1 receptor antagonist

Key Product Details

Description:	PAC₁ receptor antagonist
Chemical Name:	2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	342.35

View Full Technical Details for PA 8

Technical Data
Citations

Biological Activity for PA 8

PA 8 is a PAC₁ receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC₁, but not VPAC₁ or VPAC₂, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC₅₀ = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.

Compound Libraries for PA 8

PA 8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PA 8

M. Wt	342.35
Formula	C₁₇H₁₈N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	878437-15-1
PubChem ID	6485327
InChi Key	DCSWTWUTSKSXOV-UHFFFAOYSA-N
Smiles	COC1=C(C=CC(C2CC(NC3=C2C(N=C(N3)N)=O)=O)=C1)OCC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PA 8

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.12	50

Preparing Stock Solutions for PA 8

The following data is based on the product molecular weight 342.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.84 mL	29.21 mL	58.42 mL
2.5 mM	1.17 mL	5.84 mL	11.68 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
25 mM	0.12 mL	0.58 mL	1.17 mL

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References for PA 8

References are publications that support the biological activity of the product.

Takasaki In silico screening identified novel small-molecule antagonists of PAC₁ receptor. J.Pharmacol.Exp.Ther. 2018 PMID: 29363578