Pam3CSK4

Name: Pam3CSK4
Brand: Tocris Bioscience
SKU: 4633
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4633

(2)

Citations (34)

COA / SDS

TLR1/2 agonist; induces cytokine production

Key Product Details

Description:	TLR1/2 agonist; induces cytokine production
Purity:	≥95% (HPLC)
Molecular Weight:	1510.24

View Full Technical Details for Pam3CSK4

Technical Data
Citations / Reviews (2)

Biological Activity for Pam3CSK4

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into T_h17 cells.

Technical Data for Pam3CSK4

M. Wt	1510.24
Formula	C₈₁H₁₅₆N₁₀O₁₃S
Single Letter Sequence	CSKKKK (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	112208-00-1
PubChem ID	130704
InChi Key	OEDPHAKKZGDBEV-GFPBKZJXSA-N
Smiles	[H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pam3CSK4

Solubility

Soluble to 1mg/ml in 50% Ethanol / water

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References for Pam3CSK4

References are publications that support the biological activity of the product.

Offermanns Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 1992 PMID: 1312332
Caproni MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 2012 PMID: 22351935
St Paul Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 2012 PMID: 23116495