PAMP-20 (human)

Name: PAMP-20 (human)
Brand: Tocris Bioscience
SKU: 6552

Tocris Bioscience, part of Bio-Techne | Catalog # 6552

COA / SDS

MRGPRX2 agonist; also non-competitive nAChR antagonist

Key Product Details

Description:	MRGPRX2 agonist; also non-competitive nAChR antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	2460.87

View Full Technical Details for PAMP-20 (human)

Technical Data
Citations

Biological Activity for PAMP-20 (human)

PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC₅₀ = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

Technical Data for PAMP-20 (human)

M. Wt	2460.87
Formula	C₁₁₂H₁₇₈N₃₆O₂₇
Single Letter Sequence	ARLDVASEFRKKWNKWALSR (Modifications: Arg-20 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	150238-87-2
PubChem ID	71311703
InChi Key	PIRWNASAJNPKHT-SHZATDIYSA-N
Smiles	[H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PAMP-20 (human)

Solubility

Soluble to 1mg/ml in water

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References for PAMP-20 (human)

References are publications that support the biological activity of the product.

Kamohara Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun, 2005 PMID: 15823563
Mahata Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 1998 PMID: 9822452