Paroxetine maleate

Name: Paroxetine maleate
Brand: Tocris Bioscience
SKU: 2141

Tocris Bioscience, part of Bio-Techne | Catalog # 2141

Citations (12)

COA / SDS

Highly potent and selective 5-HT uptake inhibitor

Key Product Details

Description:	Highly potent and selective 5-HT uptake inhibitor
Chemical Name:	(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	445.44

View Full Technical Details for Paroxetine maleate

Technical Data
Citations

Biological Activity for Paroxetine maleate

Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K_i = 0.05 nM). K_i values are 1.1, 350 and 1100 nM for inhibition of [³H]-5-HT, [³H]-l-NA and [³H]-DA uptake respectively. Displays minimal affinity for α₁-, α₂- or β-adrenoceptors, 5-HT_2A, 5-HT_1A, D₂ or H₁ receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K_i = 42 nM). Antidepressant and anxiolytic in vivo.

Technical Data for Paroxetine maleate

M. Wt	445.44
Formula	C₁₉H₂₀FNO₃.C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	64006-44-6
PubChem ID	6435921
InChi Key	AEIUZSKXSWGSRU-QXGDPHCHSA-N
Smiles	OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Paroxetine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	44.54	100
	DMSO	44.54	100

Preparing Stock Solutions for Paroxetine maleate

The following data is based on the product molecular weight 445.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.22 mL	22.45 mL
5 mM	0.45 mL	2.24 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for Paroxetine maleate

References are publications that support the biological activity of the product.

Fujishiro Comparison of the anticholin. effects of the serotonergic antidepressants, paroxetine, fluvox. and clomipramine. Eur.J.Pharmacol. 2002 PMID: 12421645
Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
Bourin Paroxetine: a review. CNS Drug Rev. 2001 PMID: 11420571
Thomas Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 1987 PMID: 2962217