Paxilline

Name: Paxilline
Brand: Tocris Bioscience
SKU: 2006
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2006

(1)

Citations (487)

COA / SDS

SERCA ATPase blocker. Also potent BKCa channel blocker

Key Product Details

Description:	SERCA ATPase blocker. Also potent BK_Ca channel blocker
Chemical Name:	(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
Purity:	≥98% (HPLC)
Molecular Weight:	435.56

View Full Technical Details for Paxilline

Technical Data
Citations / Reviews (1)

Biological Activity for Paxilline

Paxilline is a potent blocker of high-conductance Ca²⁺-activated K⁺ (BK_Ca, K_Ca1.1) channels. Binds to the α-subunit of BK_Ca (K_i = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BK_Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca²⁺-ATPase (IC₅₀ = 5 - 50 μM).

Compound Libraries for Paxilline

Paxilline is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Paxilline

M. Wt	435.56
Formula	C₂₇H₃₃NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	57186-25-1
PubChem ID	105008
InChi Key	ACNHBCIZLNNLRS-UBGQALKQSA-N
Smiles	[H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Paxilline

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.56	100
	ethanol	8.71	20

Preparing Stock Solutions for Paxilline

The following data is based on the product molecular weight 435.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Paxilline

References are publications that support the biological activity of the product.

Sanchez and McManus Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 1996 PMID: 8938726
Bilmen The mechanism of inhibition of the sarco/endoplasmic reticulum Ca²⁺ ATPase by paxilline. Arch.Biochem.Biophys. 2002 PMID: 12234490
Knaus Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 1994 PMID: 7514038