PB 28 dihydrochloride

Name: PB 28 dihydrochloride
Brand: Tocris Bioscience
SKU: 2562

Tocris Bioscience, part of Bio-Techne | Catalog # 2562

(1)

Citations (5)

COA / SDS

High affinity σ2 agonist

Key Product Details

Chemical Name:	1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
Purity:	≥99%
Molecular Weight:	443.5 kDa

View Full Technical Details for PB 28 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for PB 28 dihydrochloride

PB 28 dihydrochloride is a high affinity σ₂ receptor agonist (K_i values are 0.8 and 15.2 nM for σ₂ and σ₁ receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC₅₀ values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data for PB 28 dihydrochloride

M. Wt	443.5 kDa
Formula	C₂₄H₃₈N₂O.2HCl
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	172907-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PB 28 dihydrochloride

Solubility

Soluble Soluble to 20 mM in water with gentle warming

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References for PB 28 dihydrochloride

References are publications that support the biological activity of the product.

C Cantonero, PJ Camello, C Abate, F Berardi, GM Salido, JA Rosado, PC Redondo NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines Cancers (Basel), 2020;12(2):. 2020 PMID: 31973006
Berardi et al. New σ and 5-HT_1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem., 1996;39:176 PMID: 8568804
Colabufo et al. A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol., 2003;368:106
Colabufo et al. Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol., 2004;370:106