PCI 29732

Name: PCI 29732
Brand: Tocris Bioscience
SKU: 5012

Tocris Bioscience, part of Bio-Techne | Catalog # 5012

Citations (1)

COA / SDS

Potent BTK inhibitor

Key Product Details

Description:	Potent BTK inhibitor
Chemical Name:	1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥99% (HPLC)
Molecular Weight:	371.44

View Full Technical Details for PCI 29732

Technical Data
Citations

Biological Activity for PCI 29732

PCI 29732 is a potent BTK inhibitor (IC₅₀ = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20⁺ B cells.

Compound Libraries for PCI 29732

PCI 29732 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PCI 29732

M. Wt	371.44
Formula	C₂₂H₂₁N₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	330786-25-9
PubChem ID	22347110
InChi Key	GMJUPMONHWAZCP-UHFFFAOYSA-N
Smiles	NC1=C2C(N(C4CCCC4)N=C2C3=CC=C(OC5=CC=CC=C5)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PCI 29732

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.14	100
	ethanol	18.57	50

Preparing Stock Solutions for PCI 29732

The following data is based on the product molecular weight 371.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for PCI 29732

References are publications that support the biological activity of the product.

Krishnamurty Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 2013 PMID: 23143416
Honigberg The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20615965