PCI 34051

Name: PCI 34051
Brand: Tocris Bioscience
SKU: 4643
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4643

(1)

Citations (3)

COA / SDS

Potent and selective HDAC8 inhibitor

Key Product Details

Description:	Potent and selective HDAC8 inhibitor
Chemical Name:	N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	296.32

View Full Technical Details for PCI 34051

Technical Data
Citations / Reviews (1)

Biological Activity for PCI 34051

PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC₅₀ = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.

Compound Libraries for PCI 34051

PCI 34051 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PCI 34051

M. Wt	296.32
Formula	C₁₇H₁₆N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	950762-95-5
PubChem ID	24753719
InChi Key	AJRGHIGYPXNABY-UHFFFAOYSA-N
Smiles	O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PCI 34051

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.63	100
	1eq. NaOH	5.93	20

Preparing Stock Solutions for PCI 34051

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for PCI 34051

References are publications that support the biological activity of the product.

Balasubramanian A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 2008 PMID: 18256683
Pipalia Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21436030