PD 150606

Name: PD 150606
Brand: Tocris Bioscience
SKU: 1269

Tocris Bioscience, part of Bio-Techne | Catalog # 1269

Citations (20)

COA / SDS

Cell permeable calpain inhibitor

Key Product Details

Description:	Cell permeable calpain inhibitor
Chemical Name:	(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	306.12

View Full Technical Details for PD 150606

Technical Data
Citations

Biological Activity for PD 150606

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (K_i values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

Technical Data for PD 150606

M. Wt	306.12
Formula	C₉H₇IO₂S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	179528-45-1
PubChem ID	9839500
InChi Key	DJCVSFWGKYHMKH-YVMONPNESA-N
Smiles	IC1=CC=C(/C=C(C(O)=O)\S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 150606

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.61	100
	ethanol	15.31	50

Preparing Stock Solutions for PD 150606

The following data is based on the product molecular weight 306.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.33 mL	32.67 mL
5 mM	0.65 mL	3.27 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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Reconstitution Calculator

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References for PD 150606

References are publications that support the biological activity of the product.

Wang An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8692879
Waters Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 1997 PMID: 9399991
Squier Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 1999 PMID: 9989777