PD 173074

Name: PD 173074
Brand: Tocris Bioscience
SKU: 3044
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3044

(1)

Citations (86)

COA / SDS

FGFR1 and -3 inhibitor

Key Product Details

Description:	FGFR1 and -3 inhibitor
Chemical Name:	N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	523.67

View Full Technical Details for PD 173074

Technical Data
Citations / Reviews (1)

Biological Activity for PD 173074

PD 173074 is a selective FGFR1 and FGFR3 inhibitor (IC₅₀ values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibits differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PD 173074

PD 173074 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for PD 173074

M. Wt	523.67
Formula	C₂₈H₄₁N₇O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	219580-11-7
PubChem ID	1401
InChi Key	DXCUKNQANPLTEJ-UHFFFAOYSA-N
Smiles	O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 173074

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.37	100
	ethanol	52.37	100

Preparing Stock Solutions for PD 173074

The following data is based on the product molecular weight 523.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.55 mL	19.10 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.95 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for PD 173074

References are publications that support the biological activity of the product.

Buehr Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008 PMID: 19109897
Chan PLoS One
Zhou Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J.Biol.Chem. 2010 PMID: 20705612
Pardo The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res. 2010 PMID: 19903855
Trudel Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Neoplasia 2004 PMID: 14715624
Miyake 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bla J.Pharmacol.Exp.Ther. 2010 PMID: 19955487
Bansal Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells. J.Neurosci.Res. 2003 PMID: 14598292