PD 198306

Name: PD 198306
Brand: Tocris Bioscience
SKU: 2605

Tocris Bioscience, part of Bio-Techne | Catalog # 2605

(1)

Citations (10)

COA / SDS

Selective inhibitor of MEK1/2

Key Product Details

Chemical Name:	N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide
Purity:	≥98%
Molecular Weight:	476.23 kDa

View Full Technical Details for PD 198306

Technical Data
Citations / Reviews (1)

Biological Activity for PD 198306

PD 198306 is a potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC₅₀ values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.

Technical Data for PD 198306

M. Wt	476.23 kDa
Formula	C₁₈H₁₆F₃IN₂O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	212631-61-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 198306

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for PD 198306

References are publications that support the biological activity of the product.

Ciruela et al. Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br.J.Pharmacol., 2003;138:751 PMID: 12642375
Pelletier et al. In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthrit.Rheumat., 2003;48:1582