PD 98059

Name: PD 98059
Brand: Tocris Bioscience
SKU: 1213
Rating: 5 (5 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1213

(5)

Citations (484)

COA / SDS

MEK inhibitor

Key Product Details

Description:	MEK inhibitor
Chemical Name:	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	267.28

View Full Technical Details for PD 98059

Technical Data
Citations / Reviews (5)

Biological Activity for PD 98059

PD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC₅₀ = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G₁ arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal.

Compound Libraries for PD 98059

PD 98059 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for PD 98059

M. Wt	267.28
Formula	C₁₆H₁₃NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	167869-21-8
PubChem ID	9794588
InChi Key	PKDHDJBNEKXCBI-UHFFFAOYSA-N
Smiles	COC1=C(N)C(=CC=C1)C1=CC(=O)C2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 98059

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.68	25
	ethanol	1.34	5

Preparing Stock Solutions for PD 98059

The following data is based on the product molecular weight 267.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.97 mL	74.83 mL	149.66 mL
1.25 mM	2.99 mL	14.97 mL	29.93 mL
2.5 mM	1.50 mL	7.48 mL	14.97 mL
12.5 mM	0.30 mL	1.50 mL	2.99 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PD 98059

References are publications that support the biological activity of the product.

Qi BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc.Natl.Acad.Sci.USA 2004 PMID: 15075392
Dudley A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7644477
Tsang Effects of mitogen-activated protein kinase kinase inhibitor PD 98059 on antigen challenge of guinea-pig airways in vitro. Br.J.Pharmacol. 1998 PMID: 9776345
Alessi PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J.Biol.Chem. 1995 PMID: 7499206