PEAQX tetrasodium salt

Name: PEAQX tetrasodium salt
Brand: Tocris Bioscience
SKU: 5018

Tocris Bioscience, part of Bio-Techne | Catalog # 5018

Citations (4)

COA / SDS

Potent and GluN2A-selective NMDA antagonist

Key Product Details

Description:	Potent and GluN2A-selective NMDA antagonist
Chemical Name:	[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	542.14

View Full Technical Details for PEAQX tetrasodium salt

Technical Data
Citations

Biological Activity for PEAQX tetrasodium salt

PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC₅₀ = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for PEAQX tetrasodium salt

M. Wt	542.14
Formula	C₁₇H₁₃BrN₃Na₄O₅P
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	76900415
InChi Key	QBVOZIDKUFSQIL-LPOFVUTESA-J
Smiles	C[C@@H](C3=CC=C(Br)C=C3)NC(P([O-])([O-])=O)C1=C2C(N=C([O-])C([O-])=N2)=CC=C1.[Na+].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PEAQX tetrasodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.42	10 with gentle warming

Preparing Stock Solutions for PEAQX tetrasodium salt

The following data is based on the product molecular weight 542.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.45 mL	92.23 mL	184.45 mL
0.5 mM	3.69 mL	18.45 mL	36.89 mL
1 mM	1.84 mL	9.22 mL	18.45 mL
5 mM	0.37 mL	1.84 mL	3.69 mL

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References for PEAQX tetrasodium salt

References are publications that support the biological activity of the product.

Auberson 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg.Med.Chem.Lett. 2002 PMID: 11909726