Penitrem A

Name: Penitrem A
Brand: Tocris Bioscience
SKU: 4617
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4617

(1)

Citations (13)

COA / SDS

Potent and selective KCa1.1 (BK) channel blocker

Key Product Details

Description:	Potent and selective K_Ca1.1 (BK) channel blocker
Chemical Name:	2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Purity:	≥95% (HPLC)
Molecular Weight:	634.2

View Full Technical Details for Penitrem A

Technical Data
Citations / Reviews (1)

Biological Activity for Penitrem A

Penitrem A is a potent and selective blocker of BK_Ca (K_Ca1.1) channels (IC₅₀ values are 6.4 and 64.4 nM for BK_Ca channels containing α subunits only, and those containing α and β1 respectively). Displays no effect on native delayed rectifier K⁺ and K_ATP currents, or cloned K_V1.5 channels. Blocks BK_Ca channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo.

Technical Data for Penitrem A

M. Wt	634.2
Formula	C₃₇H₄₄ClNO₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	12627-35-9
PubChem ID	6610243
InChi Key	JDUWHZOLEDOQSR-JKPSMKLGSA-N
Smiles	O[C@H]9[C@@H]([C@](C)=C)O[C@@]([C@@]%108[C@@H]9O%10)([H])CC[C@]([C@@]8(O)CC7)(C)[C@@]([C@]7([H])[C@@H]4OC(C)(C)[C@]([H])5C6)(C)C3=C4C1=C(N3)C=C(Cl)C2=C1[C@@]5(O)[C@@]6([H])C(C2)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Penitrem A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.34	10

Preparing Stock Solutions for Penitrem A

The following data is based on the product molecular weight 634.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.77 mL	78.84 mL	157.68 mL
0.5 mM	3.15 mL	15.77 mL	31.54 mL
1 mM	1.58 mL	7.88 mL	15.77 mL
5 mM	0.32 mL	1.58 mL	3.15 mL

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References for Penitrem A

References are publications that support the biological activity of the product.

Knaus Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 1994 PMID: 7514038
Asano Penitrem A as a tool for understanding the role of large conductance Ca²⁺/voltage-sensitive K⁺ channels in vascular function. J.Pharmacol.Exp.Ther. 2012 PMID: 22580348