PEP 005

Biological Activity for PEP 005

Technical Data for PEP 005

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PEP 005

References for PEP 005

References are publications that support the biological activity of the product.

• Hampson et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood, 2005;106:1362 PMID: 15845901
• Benhadji et al. Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. Br.J.Cancer, 2008;99:1808 PMID: 19034280
• Li et al. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res., 2010;70:4509 PMID: 20460505
• Kedei et al. Characterization of the interaction of ingenol-3-angelate with protein kinase C. Cancer Res., 2004;64:3243 PMID: 15126366
• Jiang et al. Synergistic reactivation of latent HIV expression by Ingenol-3-Angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation. PLoS Pathog., 2015;11:e1005066 PMID: 26225771
• Marro et al. Discovery of small molecules for the reversal of T cell exhaustion. Cell Rep., 2019;29:3293 PMID: 31801090