Pep 2-8

Name: Pep 2-8
Brand: Tocris Bioscience
SKU: 6423

Tocris Bioscience, part of Bio-Techne | Catalog # 6423

COA / SDS

Potent PCSK9 inhibitor

Key Product Details

Description:	Potent PCSK9 inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	1715.88

View Full Technical Details for Pep 2-8

Technical Data
Citations

Biological Activity for Pep 2-8

Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC₅₀ = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Technical Data for Pep 2-8

M. Wt	1715.88
Formula	C₈₃H₁₁₀N₁₆O₂₄
Single Letter Sequence	TVFTSWEEYLDWV (Modifications: Thr-1 = N-terminal Ac, Val-13 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1541011-97-5
PubChem ID	124221781
InChi Key	ORPZALWAWWEEDP-NXXUBLNKSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pep 2-8

Solubility

Soluble to 2mg/ml in PBS (pH 7.4)

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References for Pep 2-8

References are publications that support the biological activity of the product.

Zhang Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 2014 PMID: 24225950