Pexidartinib

Name: Pexidartinib
Brand: Tocris Bioscience
SKU: 7590

Tocris Bioscience, part of Bio-Techne | Catalog # 7590

Citations (2)

COA / SDS

Potent CSF-1R inhibitor

Key Product Details

Chemical Name:	N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Pexidartinib

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC₅₀ = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1⁺ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAF^V600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.

Technical Data for Pexidartinib

Formula	C₂₀H₁₅ClF₃N₅
Storage	Store at -20°C
Purity	≥98%
CAS Number	1029044-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pexidartinib

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Pexidartinib

References are publications that support the biological activity of the product.

Denardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL et al. Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy. Cancer Discov;1(1):54-67. 2011-06-01 PMID: 22039576

Pexidartinib

Tocris Bioscience, part of Bio-Techne | Catalog # 7590

Key Product Details

Biological Activity for Pexidartinib

Technical Data for Pexidartinib

Solubility for Pexidartinib

Dilution Calculator

Reconstitution Calculator

References for Pexidartinib

Product Documents for Pexidartinib

COA

Certificate of Analysis

SDS

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