PF 05175157

Name: PF 05175157
Brand: Tocris Bioscience
SKU: 5790

Tocris Bioscience, part of Bio-Techne | Catalog # 5790

Citations (6)

COA / SDS

Potent acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor

Key Product Details

Description:	Potent acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor
Chemical Name:	1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	405.49

View Full Technical Details for PF 05175157

Technical Data
Citations

Biological Activity for PF 05175157

PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC₅₀ values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 05175157

M. Wt	405.49
Formula	C₂₃H₂₇N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1301214-47-0
PubChem ID	52934180
InChi Key	BDXXSFOJPYSYOC-UHFFFAOYSA-N
Smiles	O=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 05175157

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.27	50
	ethanol	8.11	20

Preparing Stock Solutions for PF 05175157

The following data is based on the product molecular weight 405.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.93 mL	24.66 mL	49.32 mL
2.5 mM	0.99 mL	4.93 mL	9.86 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
25 mM	0.10 mL	0.49 mL	0.99 mL

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References for PF 05175157

References are publications that support the biological activity of the product.

Griffith Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 2014 PMID: 25423286