PF 05180999

Name: PF 05180999
Brand: Tocris Bioscience
SKU: 6405

Tocris Bioscience, part of Bio-Techne | Catalog # 6405

COA / SDS

Potent and selective PDE2A inhibitor

Key Product Details

Description:	Potent and selective PDE2A inhibitor
Chemical Name:	4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
Purity:	≥98% (HPLC)
Molecular Weight:	414.39

View Full Technical Details for PF 05180999

Technical Data
Citations

Biological Activity for PF 05180999

PF 05180999 is a potent and selective PDE2A inhibitor (IC₅₀ = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 05180999

PF 05180999 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 05180999

M. Wt	414.39
Formula	C₁₉H₁₇F₃N₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1394033-54-5
PubChem ID	60143346
InChi Key	CLGCHUKGBICQTE-UHFFFAOYSA-N
Smiles	CC1=NC(C2=C(C3=NC=C(C(F)(F)F)C=C3)N(C)N=C2)=C4N1N=CN=C4N5CCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 05180999

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.72	50
	ethanol	20.72	50

Preparing Stock Solutions for PF 05180999

The following data is based on the product molecular weight 414.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.83 mL	24.13 mL	48.26 mL
2.5 mM	0.97 mL	4.83 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

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References for PF 05180999

References are publications that support the biological activity of the product.

Mikami Discovery of orally bioavailable brain penetrating in vivo active phosphodiesterase 2a inhibitor series for the treatment of cognitive disorders. J.Med.Chem. 2017 PMID: 28759228