PF 06424439

Name: PF 06424439
Brand: Tocris Bioscience
SKU: 6348
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6348

(1)

Citations (5)

COA / SDS

Potent and selective DGAT2 inhibitor

Key Product Details

Description:	Potent and selective DGAT2 inhibitor
Chemical Name:	[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	536.05

View Full Technical Details for PF 06424439

Technical Data
Citations / Reviews (1)

Biological Activity for PF 06424439

PF 06424439 is a potent and selective DGAT2 inhibitor (IC₅₀ = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 06424439

M. Wt	536.05
Formula	C₂₂H₂₆ClN₇O.CH₄O₃S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1469284-79-4
PubChem ID	89854212
InChi Key	ZSTFDNQQOJUJFL-XFULWGLBSA-N
Smiles	ClC(C=N1)=CN1C2(CC2)C3=NC4=CC=C(N5C[C@H](C(N6CCCC6)=O)CCC5)N=C4N3.O=S(C)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06424439

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	53.6	100
	DMSO	53.6	100

Preparing Stock Solutions for PF 06424439

The following data is based on the product molecular weight 536.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.65 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for PF 06424439

References are publications that support the biological activity of the product.

Futatsugi Discovery and optimization of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2). J.Med.Chem. 2015 PMID: 26349027