PFI 1

Name: PFI 1
Brand: Tocris Bioscience
SKU: 4445

Tocris Bioscience, part of Bio-Techne | Catalog # 4445

Citations (6)

COA / SDS

BET bromodomain inhibitor

Key Product Details

Chemical Name:	2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for PFI 1

PFI 1 is a potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC₅₀ values are 98 and 220 nM respectively). Induces apoptosis and G₁ cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable.

Technical Data for PFI 1

Formula	C₁₆H₁₇N₃O₄S
Storage	Store at RT
Purity	≥98%
CAS Number	1403764-72-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PFI 1

Solubility

Soluble Soluble to 50 mM in DMSO

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References for PFI 1

References are publications that support the biological activity of the product.

Fish et al. Identification of a chemical probe for bromo and extra c-terminal bromodomain inhibition through optimization of a fragment-derived hit. J.Med.Chem. [Epub ahead of print], 2012; PMID: 23095041

PFI 1

Tocris Bioscience, part of Bio-Techne | Catalog # 4445

Key Product Details

Biological Activity for PFI 1

Technical Data for PFI 1

Solubility for PFI 1

Dilution Calculator

Reconstitution Calculator

References for PFI 1

Product Documents for PFI 1

COA

Certificate of Analysis

SDS

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