Picropodophyllotoxin

Name: Picropodophyllotoxin
Brand: Tocris Bioscience
SKU: 2956

Tocris Bioscience, part of Bio-Techne | Catalog # 2956

Citations (18)

COA / SDS

Selective IGF1R inhibitor

Key Product Details

Description:	Selective IGF1R inhibitor
Alternative Names:	Picropodophyllin
Chemical Name:	(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity:	≥97% (HPLC)
Molecular Weight:	414.41

View Full Technical Details for Picropodophyllotoxin

Technical Data
Citations

Biological Activity for Picropodophyllotoxin

Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC₅₀ ~ 1 nM), increases the fraction of cells in the G₂/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC₅₀ = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.

Technical Data for Picropodophyllotoxin

M. Wt	414.41
Formula	C₂₂H₂₂O₈
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	477-47-4
PubChem ID	72435
InChi Key	YJGVMLPVUAXIQN-HAEOHBJNSA-N
Smiles	O=C3OC[C@]([C@@]([H])3[C@@H]4[C@]5=CC(OC)=C(OC)C(OC)=C5)([H])[C@@H](O)C1=C4C=C(OCO2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Picropodophyllotoxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.44	100

Preparing Stock Solutions for Picropodophyllotoxin

The following data is based on the product molecular weight 414.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Picropodophyllotoxin

References are publications that support the biological activity of the product.

Stromberg IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G₂/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 2006 PMID: 16166596
Economou Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the Ins-like growth factor-1 receptor. Invest.Ophthalmol.Vis.Sci. 2008 PMID: 18515591
Girnita Cyclolignans as inhibitors of the Ins-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 PMID: 14729630