Pimozide

Name: Pimozide
Brand: Tocris Bioscience
SKU: 0937

Tocris Bioscience, part of Bio-Techne | Catalog # 0937

Citations (27)

COA / SDS

D2-like antagonist; also high affinity 5-HT7 antagonist

Key Product Details

Description:	D₂-like antagonist; also high affinity 5-HT₇ antagonist
Chemical Name:	1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	461.55

View Full Technical Details for Pimozide

Technical Data
Citations

Biological Activity for Pimozide

Pimozide is a dopamine D₂-receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT₇ receptor (K_i = 0.5 nM).

Compound Libraries for Pimozide

Pimozide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Pimozide

M. Wt	461.55
Formula	C₂₈H₂₉F₂N₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	2062-78-4
PubChem ID	16362
InChi Key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Smiles	FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pimozide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.23	20

Preparing Stock Solutions for Pimozide

The following data is based on the product molecular weight 461.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.83 mL	54.17 mL	108.33 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
2 mM	1.08 mL	5.42 mL	10.83 mL
10 mM	0.22 mL	1.08 mL	2.17 mL

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References for Pimozide

References are publications that support the biological activity of the product.

Roth Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J.Pharmacol.Exp.Ther. 1994 PMID: 7908055

Product Documents for Pimozide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Pimozide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov