PKI 14-22 amide, myristoylated

Name: PKI 14-22 amide, myristoylated
Brand: Tocris Bioscience
SKU: 2546
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2546

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Citations (41)

COA / SDS

Cell-permeable protein kinase A inhibitor

Key Product Details

Description:	Cell-permeable protein kinase A inhibitor
Alternative Names:	Protein kinase inhibitor-(14-22)-amide,myristoylated
Purity:	≥95% (HPLC)
Molecular Weight:	1209.5

View Full Technical Details for PKI 14-22 amide, myristoylated

Technical Data
Citations / Reviews (1)

Biological Activity for PKI 14-22 amide, myristoylated

PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (K_i = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data for PKI 14-22 amide, myristoylated

M. Wt	1209.5
Formula	C₅₃H₁₀₀N₂₀O₁₂
Single Letter Sequence	GRTGRRNAI (Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	201422-03-9
PubChem ID	71312213
InChi Key	GQPQKQWUUHDDIS-JDLJUXOTSA-N
Smiles	[H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PKI 14-22 amide, myristoylated

Solubility

Soluble to 1mg/ml in DMSO

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References for PKI 14-22 amide, myristoylated

References are publications that support the biological activity of the product.

Zheng Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 2000 PMID: 10829013
Farrow Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 2003 PMID: 12947318
Glass Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 1989 PMID: 2722799