PNU 37883 hydrochloride

Name: PNU 37883 hydrochloride
Brand: Tocris Bioscience
SKU: 2095
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2095

(1)

Citations (4)

COA / SDS

Vascular Kir6 (KATP) channel blocker

Key Product Details

Description:	Vascular K_ir6 (K_ATP) channel blocker
Chemical Name:	N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	381.98

View Full Technical Details for PNU 37883 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for PNU 37883 hydrochloride

PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of K_ir6 (K_ATP) channel; inhibits K_ir6 currents in isolated mesenteric artery smooth muscle cells (K_d = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Compound Libraries for PNU 37883 hydrochloride

PNU 37883 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PNU 37883 hydrochloride

M. Wt	381.98
Formula	C₂₁H₃₅N₃O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	57568-80-6
PubChem ID	64392
InChi Key	FZALCKUJYZCDOX-UHFFFAOYSA-N
Smiles	C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PNU 37883 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.55	25
	ethanol	38.2	100

Preparing Stock Solutions for PNU 37883 hydrochloride

The following data is based on the product molecular weight 381.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.09 mL	26.18 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for PNU 37883 hydrochloride

References are publications that support the biological activity of the product.

Cui Different molecular sites of action for the K_ATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 2003 PMID: 12746230
Kovalev Molecular analysis of the subtype-selective inhibition of cloned K_ATP channels by PNU-37883A. Br.J.Pharmacol. 2004 PMID: 14757705
Humphrey and Ludens K_ATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 1998 PMID: 9641474