Pomalidomide 4'-alkylC5-acid

Name: Pomalidomide 4'-alkylC5-acid
Brand: Tocris Bioscience
SKU: 6682

Tocris Bioscience, part of Bio-Techne | Catalog # 6682

COA / SDS

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Key Product Details

Description:	Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Alternative Names:	Pomalidomide - linker 3
Chemical Name:	6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	387.39

View Full Technical Details for Pomalidomide 4'-alkylC5-acid

Technical Data
Citations

Biological Activity for Pomalidomide 4'-alkylC5-acid

Pomalidomide 4'-alkylC5-acid is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 3

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Pomalidomide 4'-alkylC5-acid

M. Wt	387.39
Formula	C₁₉H₂₁N₃O₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2225940-49-6
PubChem ID	134501173
InChi Key	FOHDGJCYBZWKCE-UHFFFAOYSA-N
Smiles	OC(CCCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Pomalidomide 4'-alkylC5-acid

References are publications that support the biological activity of the product.

Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626