Degrader Building Blocks: Small Molecules and Peptides
155 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
155 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
Degrader Building Blocks: Small Molecules and Peptides
UBE2D degrader building block
| Chemical Name: | N-[[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl]-2-propenamide |
| Purity: | ≥95% (HPLC) |
Functionalized VHL building block for copper-free click chemistry
| Chemical Name: | ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate |
| Purity: | ≥90% (HPLC) |
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
| Chemical Name: | 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid |
| Purity: | ≥90% (HPLC) |
Biotinylated ASGPR ligand for LYTAC research and development
| Purity: | ≥90% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C3-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG3-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% |
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
| Chemical Name: | N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide |
| Purity: | ≥90% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name: | 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid |
| Purity: | ≥95% (HPLC) |
IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-2-[(2-aminoethoxy)ethoxy]ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | Pomalidomide - linker 7 |
| Chemical Name: | 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Functionalized IAP ligand for PROTACs
| Chemical Name: | tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | (2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥94% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | (2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | Pomalidomide - linker 4 |
| Chemical Name: | 4-[(5-Aminopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-C7-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride |
| Purity: | ≥95% (HPLC) |
Functionalized VHL ligand for PROTACs
| Chemical Name: | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand, carboxylic acid functionalized at the benzylic position
| Chemical Name: | (S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 4-[(8-Aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG5-COOH |
| Chemical Name: | (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
