PPT

Name: PPT
Brand: Tocris Bioscience
SKU: 1426
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1426

(1)

Citations (40)

COA / SDS

Subtype-selective ERα agonist

Key Product Details

Description:	Subtype-selective ERα agonist
Chemical Name:	4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Purity:	≥99% (HPLC)
Molecular Weight:	386.45

View Full Technical Details for PPT

Technical Data
Citations / Reviews (1)

Biological Activity for PPT

PPT is a potent, subtype-selective estrogen receptor agonist (EC₅₀ ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.

Compound Libraries for PPT

PPT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PPT

M. Wt	386.45
Formula	C₂₄H₂₂N₂O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	263717-53-9
PubChem ID	6095481
InChi Key	UOSWGERPQQOSHS-UHFFFAOYSA-N
Smiles	CCCC1=C(N(N=C1C1=CC=C(O)C=C1)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PPT

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	1.93	5
	DMSO	38.65	100

Preparing Stock Solutions for PPT

The following data is based on the product molecular weight 386.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.94 mL	25.88 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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Reconstitution Calculator

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References for PPT

References are publications that support the biological activity of the product.

Kraichely Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 2000 PMID: 11014206
Stauffer Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J.Med.Chem. 2000 PMID: 11150164
Harris Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 2002 PMID: 12399409

PPT