Prasugrel

Name: Prasugrel
Brand: Tocris Bioscience
SKU: 6317

Tocris Bioscience, part of Bio-Techne | Catalog # 6317

COA / SDS

Irreversible P2Y12 antagonist; antiplatelet and orally active

Key Product Details

Description:	Irreversible P2Y₁₂ antagonist; antiplatelet and orally active
Alternative Names:	LY640315,CS 747,Effient
Chemical Name:	2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Purity:	≥98% (HPLC)
Molecular Weight:	373.44

View Full Technical Details for Prasugrel

Technical Data
Citations

Biological Activity for Prasugrel

Prasugrel is an irreversible P2Y₁₂ antagonist; metabolised to active metabolite R-99224 (IC₅₀ = 45 μM) irreversibly binds platelet P2Y₁₂ receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.

Compound Libraries for Prasugrel

Prasugrel is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prasugrel

M. Wt	373.44
Formula	C₂₀H₂₀FNO₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	150322-43-3
PubChem ID	6918456
InChi Key	DTGLZDAWLRGWQN-UHFFFAOYSA-N
Smiles	CC(OC1=CC2=C(S1)CCN(C(C3=C(C=CC=C3)F)C(C4CC4)=O)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Prasugrel

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.34	100

Preparing Stock Solutions for Prasugrel

The following data is based on the product molecular weight 373.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for Prasugrel

References are publications that support the biological activity of the product.

Hashimoto The influence of P2Y₁₂ receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y₁₂ receptors by pras. Biochem.Pharmacol. 2007 PMID: 17681285
Huber Prasugrel. Nat.Rev.Drug Discov. 2009 PMID: 19483707
Sugidachi The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 2000 PMID: 10742300