PRE-084 hydrochloride

Name: PRE-084 hydrochloride
Brand: Tocris Bioscience
SKU: 0589

Tocris Bioscience, part of Bio-Techne | Catalog # 0589

(2)

Citations (16)

COA / SDS

Highly selective σ1 agonist

Key Product Details

Chemical Name:	2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
Purity:	≥99%
Molecular Weight:	353.89 kDa

View Full Technical Details for PRE-084 hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for PRE-084 hydrochloride

PRE-084 hydrochloride is a high affinity, selective σ₁ agonist (K_i values are 2.2 and 13091 nM for σ₁ and σ₂ receptors respectively). Selective over PCP receptors (IC₅₀ > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling.

Technical Data for PRE-084 hydrochloride

M. Wt	353.89 kDa
Formula	C₁₉H₂₇NO₃.HCl
Storage	Store at RT
Purity	≥99%
CAS Number	138847-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PRE-084 hydrochloride

Solubility

Soluble Soluble to 25 mM in water and to 75 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PRE-084 hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Szabo A, Kovacs A, Frecska E, Rajnavolgyi E Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS ONE, 2014;9(8):e106533. 2014 PMID: 25171370
Brown et al. Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br.J.Pharmacol., 2004;141:233 PMID: 14691051
Maurice et al. The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (σ) receptor ligands involves both σ1 and σ2 sites. Br.J.Pharmacol., 1999;127:335 PMID: 10385231
Su et al. Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand. J.Pharmacol.Exp.Ther., 1991;259:543 PMID: 1658302
Hyrskyluoto et al. Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway. Cell Death Dis., 2013;4:e646 PMID: 23703391