[Pro³]-GIP (Mouse)

Name: [Pro 3 ]-GIP (Mouse)
Brand: Tocris Bioscience
SKU: 5838

Tocris Bioscience, part of Bio-Techne | Catalog # 5838

Citations (1)

COA / SDS

GIP receptor antagonist

Key Product Details

Description:	GIP receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	4971.62

View Full Technical Details for [Pro³]-GIP (Mouse)

Technical Data
Citations

Biological Activity for [Pro³]-GIP (Mouse)

[Pro³]-GIP (Mouse) is a GIP receptor antagonist (IC₅₀ = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.

Technical Data for [Pro³]-GIP (Mouse)

M. Wt	4971.62
Formula	C₂₂₅H₃₄₂N₆₂O₆₄S
Single Letter Sequence	YAPGTFISDYSIAMDKIRQQDFVNWLLAQRGKKSDWKHNITQ
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	121513896
InChi Key	MAEZQGLUYPOMQT-DYJGCSTISA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [Pro³]-GIP (Mouse)

Solubility

Soluble to 2mg/ml in water

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References for [Pro³]-GIP (Mouse)

References are publications that support the biological activity of the product.

Gault Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent Insotropic polypeptide. Biochem.Biophys.Res.Commun. 2002 PMID: 11820780
Irwin Early administration of the glucose-dependent Insotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 2007 PMID: 17486314

[Pro³]-GIP (Mouse)

Tocris Bioscience, part of Bio-Techne | Catalog # 5838

Key Product Details

Biological Activity for [Pro³]-GIP (Mouse)

Technical Data for [Pro³]-GIP (Mouse)

Solubility for [Pro³]-GIP (Mouse)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [Pro³]-GIP (Mouse)

Product Documents for [Pro³]-GIP (Mouse)

COA

Certificate of Analysis

SDS

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[Pro3]-GIP (Mouse)

Tocris Bioscience, part of Bio-Techne | Catalog # 5838

Key Product Details

Biological Activity for [Pro3]-GIP (Mouse)

Technical Data for [Pro3]-GIP (Mouse)

Solubility for [Pro3]-GIP (Mouse)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [Pro3]-GIP (Mouse)

Product Documents for [Pro3]-GIP (Mouse)

COA

Certificate of Analysis

SDS

[Pro³]-GIP (Mouse)

Biological Activity for [Pro³]-GIP (Mouse)

Technical Data for [Pro³]-GIP (Mouse)

Solubility for [Pro³]-GIP (Mouse)

References for [Pro³]-GIP (Mouse)

Product Documents for [Pro³]-GIP (Mouse)