Prosaptide TX14(A)

Name: Prosaptide TX14(A)
Brand: Tocris Bioscience
SKU: 5151

Tocris Bioscience, part of Bio-Techne | Catalog # 5151

Citations (3)

COA / SDS

Potent GPR37 and GPR37L1 agonist

Key Product Details

Description:	Potent GPR37 and GPR37L1 agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1579.72

View Full Technical Details for Prosaptide TX14(A)

Technical Data
Citations

Biological Activity for Prosaptide TX14(A)

Prosaptide TX14(A) is a potent GPR37L1 and GPR37 agonist (EC₅₀ values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.

Technical Data for Prosaptide TX14(A)

M. Wt	1579.72
Formula	C₆₉H₁₁0N₁₆O₂₆
Single Letter Sequence	TALIDNNATEEILY (Modification: Ala-2 = D-Ala)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	196391-82-9
PubChem ID	16197909
InChi Key	SMUKRAODILXPSW-SRWCCNGVSA-N
Smiles	[H]N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Prosaptide TX14(A)

Solubility

Soluble to 2mg/ml in water

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References for Prosaptide TX14(A)

References are publications that support the biological activity of the product.

Meyer GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 2013 PMID: 23690594
Hiraiwa Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 1997 PMID: 9114068