proTAME

Name: proTAME
Brand: Tocris Bioscience
SKU: 7734

Tocris Bioscience, part of Bio-Techne | Catalog # 7734

Citations (4)

COA / SDS

Cell-permeable APC/C inhibitor

Key Product Details

Description:	Cell-permeable APC/C inhibitor
Chemical Name:	Methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoate
Purity:	≥90% (HPLC)
Molecular Weight:	726.75

View Full Technical Details for proTAME

Technical Data
Citations

Biological Activity for proTAME

ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.

Technical Data for proTAME

M. Wt	726.75
Formula	C₃₄H₃₈N₄O₁₂S
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1362911-19-0
PubChem ID	56924780
InChi Key	MHYOVHULCQSDRZ-NDEPHWFRSA-N
Smiles	O=C([C@@H](NS(=O)(C1=CC=C(C=C1)C)=O)CCC/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)/NC(OCOC(CC3=CC=CC=C3)=O)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for proTAME

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.34	50

Preparing Stock Solutions for proTAME

The following data is based on the product molecular weight 726.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.75 mL	13.76 mL	27.52 mL
2.5 mM	0.55 mL	2.75 mL	5.50 mL
5 mM	0.28 mL	1.38 mL	2.75 mL
25 mM	0.06 mL	0.28 mL	0.55 mL

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References for proTAME

References are publications that support the biological activity of the product.

Zeng Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010 PMID: 20951947