PSB 12379

Name: PSB 12379
Brand: Tocris Bioscience
SKU: 6083

Tocris Bioscience, part of Bio-Techne | Catalog # 6083

Citations (7)

COA / SDS

Ecto-5'-nucleotidase (CD73) inhibitor

Key Product Details

Description:	Ecto-5'-nucleotidase (CD73) inhibitor
Chemical Name:	N⁶-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	559.31

View Full Technical Details for PSB 12379

Technical Data
Citations

Biological Activity for PSB 12379

PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (K_i values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.

Technical Data for PSB 12379

M. Wt	559.31
Formula	C₁₈H₂₁N₅Na₂O₉P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	131648246
InChi Key	CGXINRNHTNDEBI-BUPZQQHBSA-L
Smiles	O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 12379

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for PSB 12379

References are publications that support the biological activity of the product.

Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578
Bhattarai α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 2015 PMID: 26147331